Mission:
We design cell factories to make protein expression as quick, simple, and inexpensive as possible.
A Better Way to Express Proteins
Most protein production systems were not designed for high-throughput or scale. They make proteins inside the cell, where they often form insoluble inclusion bodies or get contaminated when the cell is broken open during recovery.
We take a different approach.
Direct Secretion
Proteins are secreted into the surrounding media, eliminating cell lysis and simplifying recovery.
Functional Output
Produces soluble, active proteins across multiple protein classes including enzymes, peptides, and growth factors
Built for High-Throughput
Compatible with high-throughput screening workflows and scalable fermentation systems.
High Purity from the Start
Opera was founded on the idea that making or sourcing a protein should not stretch your budget or slow your research down. We know that making a protein is hard, and purifying it is even harder. So, we took the easiest and fastest way to make proteins (in E. coli) and made it even simpler.
Our bacteria can secrete proteins out of the cell in a single step to give you a soluble, active protein with starting purities up to 90%.
Let us help you with your protein problems
Research Services
If you have an interesting protein target, talk to us about a feasibility screening to see if your protein is a good candidate for protein secretion.
Manufacturing Proteins
If you're looking for a manufacturing solution to a protein you need beyond the screening stage, we can offer scale-up services up to 10L and have partnerships for even larger scale if needed.
Partners:
We work with partners developing protein-based products where expression,s creening, or scale-up is a limiting cactor.
We have customers that include some of the largest global biotechs, startups, government labs, and many more.
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GET IN TOUCH
We want to hear about your protein projects and talk about how we can help. Contact us today to discuss a secretion feasibility project.
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